Abstract
目的 研究携带Panton-Valentine杀白细胞素(Panton-Valentine leukocidin,PVL)基因金黄色葡萄球菌所致感染类型.方法 利用多重PCR检测金黄色葡萄球菌临床分离株的PVL基因,应用多位点基因序列分型(multilocus sequence typing,MLST)技术对PVL基因阳性的菌株进行序列分型,耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)的SCCmec基因分型采用多重PCR.结果 26株携带PVL基因的金黄色葡萄球菌有13株为ST88,5株为ST239,5株为ST398,ST25、ST30和ST59各1株.20株为医院获得株,主要引起肺部感染和术后伤口化脓性感染;6株为社区感染株,主要引起软组织化脓性感染.7株MSSA全部为ST88,主要引起化脓性感染.而19株MRSA分布在6种ST型中,主要有ST88-SCCmec Ⅲ A、ST239-SCCmec Ⅲ、ST398-SCCmec Ⅳ和ST398-SCCmec Ⅲ.26株菌株分布于14个病区,在产科发生过携带PVL基因的ST88-SCCmec Ⅲ AMRSA克隆株的播散.结论 本院分离的携带PVL基因的金黄色葡萄球菌的序列型主要为ST88、ST239和ST398,既可造成医院感染也可造成社区感染且可能引起克隆株的播散。
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