Abstract
Study on immune changes and correlation of T regulatory cells and IL-35 in the early phase of rat model of acute pancreatitis
Highlights
Acute pancreatitis is a severe medical condition related to high mortality and morbidity
No significant changes were noticed in the control group. (Figure 2a) Under microscopy, the acinar lobules were intact with clear stroma and mild interstitial edema. (Figure 2b & 2c) Microscopical evidence of hemorrhage, necrosis, and abundant interstitial mononuclear inflammatory cells was observed (Figure 3)
Changes in Treg and IL - 35 levels in peripheral blood and their correlation with pathologic grading of pancreas: In the control group blood Treg was found 2.706% while in the AP group the average value was less than 2%. 2 hours after modeling in AP group this value was 1.735% on an average
Summary
Acute pancreatitis is a severe medical condition related to high mortality and morbidity. This condition refers to a state of imbalance in host immunological stress and immunosuppressive activity. T regulatory cells or Tregs and IL35 are one of the regulatory mechanisms that are responsible for the maintenance of the host the immune response and tolerance to self-antigens and autoimmune disease process. Various inflammatory mediators and cytokines are produced which leads to immunological changes, increase in infection status along with the loss of functional capacity of organs [1]. We intended to investigate the potential correlation and changes of Treg and IL35 in the peripheral blood in the early phase of the rat model of acute pancreatitis
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