Abstract
The hypoglycemic activity of extracts from muscles of pigs (Sus scrofa; P), chickens (Gallus domesticus; C) and mackerel (Scomber japonicus; M) was examined. P exhibited an insulin-like activity on conversion of glucose to total lipids in rat free fat cells and an insulin secretion-promoting effect on perfused rat pancreas. C showed an insulin-like activity, an insulin secretion-promoting effect and an inhibitory effect on hepatic glycogenolysis. M proved to have a weak insulin-like activity, and a weak insulin secretion-promoting effect, but its inhibitory effect on hepatic glycogenolysis was strong.After intraperioneal administration of P, C and M, the blood glucose levels decreased in both normal mice and alloxan-induced diabetic mice.
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