Study on hot property differences of Aconiti Lateralis Radix Praeparata and its compatibility with different ginger processed products based on bio-thermodynamics

Abstract

Aconiti Lateralis Radix Praeparata (ALRP) is commonly used traditional Chinese medicine in clinic, and it is usually in compatibility with ginger including Zingiberis Rhizoma (ZR), Zingiberis Rhizoma Recens (ZRR), and Zingiberis Rhizoma Praeparatum (ZRP) for treatment of diseases. In this paper, microcalorimetry and Cold/Hot plate differentiating technology (CHPD) were employed to explore the hot property differences of ALRP, together with its compatibility with different ginger processed products. By means of principal component analysis (PCA), the heat power of the second peak (P2) and the total heat output (Q) which were the main parameters affecting the E. coli metabolism from the power-time curves were obtained. The results showed that the hot property of ALRP in compatibility with different processed ginger was in order of ZR + ALRP > ZRR + ALRP > ZRP + ALRP > ALRP. Meanwhile, the oxygen consumption and remaining rate (RR) in mice on warm plate suggested that the hot property of ALRP was totally different. The relationships between the main parameters (P2 and Q) values and the observation indexes from CHPD were investigated with canonical correlation analysis. The correlation coefficient showed that parameter Q had a marked correlation with the observation indexes (R > 0.85). Altogether, based on bio-thermodynamics, the hot property differences of ALRP and its compatibility with different ginger processed products followed the order of ZR + ALRP > ZRR + ALRP > ZRP + ALRP > ALRP. This could provide guidance for clinical use of ALRP combining with different ginger processed products.