Study on HemoTypeSC™ test for the rapid screening of sickle cell disease patients in Government Medical College and Hospital, Ambikapur

Abstract

Background: Sickle cell disease (SCD), also known as sickle cell anemia, is a dangerous disease in which the body produces an abnormal form of hemoglobin, the protein in red blood cells that transport oxygen throughout the body. The body produces sickle- or crescent-shaped red blood cells as a result of this genetic change. Aims and Objectives: This study aims to study on HemoTypeSC™ test for the rapid screening of SCD patients in Government Medical College and Hospital, Ambikapur. Materials and Methods: Fifty patients have been diagnosed as sickle cell anemia by sickle cell solubility test at Govt. Medical College, Ambikapur, Chhattisgarh,India. All the patients were admitted in the Department of Medicine at Govt. Medical College, Ambikapur, Chhattisgarh,India, from April 1, 2021, to June 1, 2021. Results: The study group (HbSS patients) comprised 22 (42%) males and 28(58%) females.The ages ranged from 1 to 45 years; these 50 patients have been diagnosed as sickle cell anemia by sickle cell solubility test positive at Govt.Medical College, Ambikapur, Chhattisgarh,India. Conclusion: Sickle cell illness can be counted and observed in a variety of ways. Experience includes things such as electrophoresis and hand counting. HemoTypeSC™ is a blood test kit that determines hemoglobin type in whole blood in a short amount of time. At the point of care, this test detects the hemoglobin phenotype HbAA (normal), HbSS and HbSC (SCD), HbCC (hemoglobin C illness), and HbAS and HbAC (carrier or trait). Monoclonal antibodies are highly specific and sensitive to hemoglobin’s A, S, and C. The fetal hemoglobin has no effect. There are no liquid buffer components or requirements for refrigeration. In high temperatures, it remains stable and the test takes only 10 min to complete.