Study on frequency and risk factors for secondary infections among COVID-19 individuals

Abstract

Secondary Infections (SIs) refer to infections that occur in addition to the initial Corona Virus Disease 2019 (COVID-19) infection. These SI can be caused by bacteria, fungi, or other viruses and they can complicate the clinical course of the disease, leading to worse outcomes. The purpose of the study is to describe the incidence as well as danger factors for SIs in people with COVID-19 diagnoses. This statement describes the methodology used in an ensemble study of COVID-19 individuals who were hospitalized at Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), from February to April 2020, San Raffaele Hospital. In the study's 731 individuals, 68 had SIs, which resulted in an overall 28-day cumulative frequency and risk factors. Infections with gram-positive bacteria, particularly coagulase-negative staphylococcus have been accountable for most bloodstream infections (BSIs), but gram-negative pathogens, such Acinetobacter baumannii and Escherichia coli, were less frequent. Eleven people were identified in the investigation as possibly suffering from significant aspergillosis. Following the very first 48 hours following residential therapy, the individual was brought to the Intensive-Care Unit (ICU) due to an insufficient initial lymphocytes level. The finding that early need for ICU has been connected to a higher chance of developing infections in the future highlights the importance of prompt and appropriate treatment for individuals with serious COVID-19.