Abstract
The objective of this paper was to study the extraction methods of tannin constituents from Semen Cuscutae and their anti-papilloma effects. Single factor test and orthogonal design methods were used to determine the optimal extraction method; the mouse skin papilloma model induced by DMBA/croton oil was established, which was a classic two-stage carcinogenesis model being used to observe and evaluate the anti-carcinogenic effects of tannins extracted from Semen Cuscutae in different stages. The optimal extraction method of Semen Cuscutae was a 20-fold volume of solvent, a temperature of 50 °C, three times of extraction, with 20 min each, skin papilloma experiment revealed that the number of bearing tumors gradually reduced, and the inhibition rate gradually increased with the increase of dose, in the high-dose group, its inhibition rate reached 70.2%. Tannin extract from Semen Cuscutae has an obvious inhibitory effect on skin papilloma development.
Highlights
IntroductionSemen Cuscutae is the dried mature seeds of Cuscuta chinensis Lam. in the Convolvulaceae family, which is called Longxuzi, Tusizi, etc and bought from Anguo Ltc. in Henan
Semen Cuscutae is the dried mature seeds of Cuscuta chinensis Lam. in the Convolvulaceae family, which is called Longxuzi, Tusizi, etc and bought from Anguo Ltc. in Henan. It is mainly distributed in Liaoning, Jilin, and Hebei of China
It is sweet in taste, neutral in nature, and has the effects of nourishing liver and kidney, securing essence and reducing urination, preventing miscarriage, improving eyesight, and arresting bleeding
Summary
Semen Cuscutae is the dried mature seeds of Cuscuta chinensis Lam. in the Convolvulaceae family, which is called Longxuzi, Tusizi, etc and bought from Anguo Ltc. in Henan. It is mainly distributed in Liaoning, Jilin, and Hebei of China. Its pharmacological effects are mainly manifested in the reproductive system, immune system, anti-oxidation, and anti-mutation aspects It is commonly used in the prevention and treatment of cardiovascular diseases, protection of liver, improvement of eyesight, and enhancement of immunity (Wu et al, 2009; Li et al, 2009; Song et al, 2010; Liu et al, 2004)
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