Abstract

The antigen Alpha-subunit of human chorionic gonadotropin (α-HCG) and α-HCGmRNA in pancreatic endocrine tumors (PET) were investigated by immunohistochemistry andin situ hybridization. It was found that α-HCG can be detected in PET buy not in normal islet cells. α-HCG immunoreactivity was expressed by 5 of 28 (18%) in benign PET and 14 of 24 (58.3%) in malignant PET. Usingin situ hybridization of α-HCGmRNA, a strong signal in PET was obtained. The clinico-pathological significance of α-HCG in PET was discussed.

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