Study on event related potentials and behavioral characteristics in Go/Nogo task in children with sleep disordered breathing and normal children

Abstract

Objective To compare and analyze the event related potential (ERP) and behavioral characteristics of sleep disordered breathing (SDB) and normal children by the persistent operating test (CPT-AX) task, and to explore the characteristics and neural mechanism of the cognitive deficits in the left and right brain of school age SDB children. Methods SDB children(n=20) and normal children(n=20) aged 6-8 were selected.All subjects were tested by CPT-AX (Go/Nogo task). The ERP behavior of SDB and normal children was recorded, and the N2, P3 amplitude and latency of F3, Fz, F4 lead were compared. Results (1)There was no significant difference between SDB group and normal group in behavioral correct number (36.45±4.69 vs 35.00±3.46), the reaction time ((516.84±54.14)ms vs (496.94±78.89)ms) and false alarm number(1.0 (0.25, 3.75) vs 0.5 (0.00, 3.00)) (all P>0.05). (2)Comparison of F3, Fz and F4 lead: (1) SDB group: there was no significant difference in Go-N2 amplitude (-7.75(-12.03, -1.09)μV vs (-8.69±5.72) μV vs ( -7.12±4, 68)μV) and Nogo-N2 amplitude((-10.72±4.49)μV vs (-12.16±4.60) μV vs (-11.78±4.44) μV) in the left, middle, and right of frontal regions.(2) Control group: there was no statistical difference between F3 and Fz ((-7.26±3.18)μV vs (-9.09±3.11)μV)(P>0.05) in N2 amplitude and there was no statistical difference between F3 and F4((-7.26±3.18) μV vs (-6.10±3.36)μV) in N2 amplitude (P>0.05). The N2 amplitude difference of Fz and F4 ((-9.09±3.11) μV vs (-6.10±3.36)μV ) was statistically significant (P 0.05). The left frontal lobe Nogo-N2 amplitude was significantly higher than that of the right frontal lobe((-14.05±3.31) μV vs -11.75(-12.68, -10.43) μV) (P 0.05). Conclusion Compared with normal children, SDB children showed no left dominant brain region while dealing with the same conflict monitoring tasks.It is suggested that left hemisphere activation is poor and function is incompatible.Left frontal lobe injury in SDB is more obvious than that in the right side. Key words: Sleep disordered breathing; Children; Attention; Left and right cerebral hemispheres; Event-related potential; Continuous performance test