Abstract
Introduction: The periurethral and transition zones of the prostatic gland develop benign prostatic hyperplasia and represent an inevitable phenomenon for the ageing male population. Prostatic specific antigen, is a serine protease, level rises in the blood if the barrier between thelining epithelium and the blood stream is damaged. Benign prostatic hyperplasia, prostatic carcinoma and prostatitis are three common diseases where PSA in the serum is raised. Prostate volume also increases according to age, which can be estimated by trans-abdominal ultrasonography.
 Objective: The aim of the study is to estimate the PSA level in blood and its relationship with prostate volume in benign prostatic hyperplasia patients.
 Methodology: It is a descriptive cross-sectional study which was carried out between a periods of 1st April 2018 to 31st March 2019 at Birat Medical College Teaching Hospital. All the patients diagnosed with benign prostate hyperplasia at the department of urology were included in the study. Blood samples of patients were analyzed for Prostate specific antigen level estimation by chemiluminescence immunosorbent assay. Prostatic volume of the patients was measured by Transabdominal ultrasound technique. Data were entered and analyzed in Microsoft Excel.
 Results: A total of 68 patients were diagnosed with benign prostate hyperplasia. The mean age of the patients was 61.8±12.3 years. The maximum number 23 of patients with BPH was there in age group 51-60. The maximum no of patients 38 were having their PSA level between the range of 4.0-10.0 ng/ml. The maximum no of patients 28 was having Prostate volume in the range of 40-60 gm. The maximum number of patients 31 was having diabetes mellitus as a co-morbid association. The maximum mean PSA level and prostate volume in the patients were observed in age group >80 years,which was 20.1±8.6 ng/ml and >80 gm respectively.
 Conclusion: The prostate specific antigen level and prostate volume both increase in advance age group of patients suffering with benign prostate hyperplasia.
Highlights
Benign prosta c hyperplasia arises in the periurethral and transi on zones of the prosta c gland and represents an inevitable phenomenon for the ageing male popula on
The prostate specific an gen level and prostate volume both increase in advance age group of pa ents suffering with benign prostate hyperplasia
In this study the Prostate specific an gen (PSA) level showed significant correla on with both pa ent age and weight of the prostate gland (P < 0.05), the weight of the gland was significantly correlated with the age of the pa ent (P
Summary
Benign prosta c hyperplasia arises in the periurethral and transi on zones of the prosta c gland and represents an inevitable phenomenon for the ageing male popula on. Prosta c enlargement that may due to any cause may give rise to bladder outlet obstruc on.1Benign prosta c hyperplasia (BPH) is a progressive condi on characterized by prostate enlargement accompanied by lower urinary tract symptoms. An es mated 75% of men >50 years of age have symptoms arising from benign prosta c hyperplasia, and 20–30% of men reaching 80 years of age require surgical interven on for the management of BPH.[2] Prostate is a male specific organ and the rate of clinical symptoms due to obstruc on of the bladder neck goes up as the age rises due to increase in prosta c volume.[3] BPH affects both glandular epithelium and connec ve ssue stroma to variable degrees in which adenosis, epitheliosis and stromal prolifera on are seen in differing propor ons.[4]
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