Study on eosinophilic and Lymphocytic esophagitis in patients with typical gastroesophageal reflux disease symptoms

Abstract

Background: Eosinophilic esophagitis (EoE) has emerged as an important gastrointestinal (GI) disorder during the last 15 years, affecting approximately 15% of patients with dysphagia EoE presents a diagnostic challenge because eosinophils are also a feature of acid-induced esophagitis.The aim of this study was to evaluate prospectively the presence of eosinophilic and lymphocytic esophagitis in patients with typical gastroesophageal reflux disease symptoms. Patients and Methods: This was a prospective study which was conducted on 200 patients, to estimate the prevalence of eosinophilic and lymphocytic esophagitis in patients with typical gastroesophageal reflux disease symptoms.Results: Regarding serum IgE as laboratory investigation, all the cases 6 (100%) diagnosed to have EoE showed elevated level of serum IgE level ((normal range was used according to the laboratory was: 0 – 165 IU/ml). There was statistical significance for the presence of elevated serum IgE level and peripheral serum eosinophilia between positive and negative cases for EoE Conclusion: Eosinophilic esophagitis is not uncommon disease and presented in 6 cases out of 200 patients having typical symptoms of GERD. All the positive EoE cases having history of allergy and most of them are asthmatic.