Abstract
The purpose of this study is to investigate the effects of γ-aminobutyric acid on sleep improvement in mice. According to the method of Technical Standard for Health Food Inspection and Evaluation, animals were divided into three experimental groups. Group 1: Directly inducing sleep and prolonging sleep time experiment; Group 2: Subthreshold dose of sodium pentobarbital for hypnosis experiment; Group 3: Shortening sleep latency experiment. In each experimental group, 40 mice were randomly divided in four subgroups according to their body weight. After 30 days’ oral intake of different doses of γ-aminobutyric acid by mice, it is found that γ-aminobutyric acid can prolong the sleep time of mice hypnotized by pentobarbital sodium and shorten the sleep latency of mice hypnotized by barbital sodium. Meanwhile, there were no obvious abnormal changes in weight of mice. No side-effects were observed during the experiments. These results demonstrate that γ-aminobutyric acid produced by Bloomage Biotechnology Corporation Limited, has sleep aid function.
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