Study on early warning role of rectal aberrant crypt foci of colorectal cancer and progressive adenoma and risk factors

Abstract

Objective To investigate the early warning role of rectal aberrant crypt foci (ACF) for colorectal cancer, progressive adenoma and the related risk factors. Methods Clinical data of 564 patients receiving full colonoscopy and rectum staining observation from January 2014 to September 2015 were retrospectively analyzed. According to the bowel examination results, they were divided into normal group, advanced adenoma group and colorectal cancer group. The early warning function and its risk factors were analyzed and discussed. Results The number of ACF in progressive adenoma group and colorectal cancer group was significantly higher than the normal group, the difference was statistically significant (P 60 years and smoking were independent risk factors in patients with ACF, while aspirin was a protective factor (P<0.05). Conclusions Grade Ⅲ ACF patients are prone to develop progressive adenoma and colorectal cancer, grade Ⅱ patients are with a higher risk of colorectal cancer. ACF patients are with risk factors for older age, smoking, while taking aspirin as a protective factor. Key words: Colorectal neoplasms; Aberrant crypt foci; Risk factors; Adenoma