Study on Distribution of Magnetite (Fe3-xMnxO4) Filler in Fe3-xMnxO4-PEG/PVA/PVP Magnetic Hydrogel by Using Twolognormal Function Analysis

Abstract

The trend of nanoparticles technology has been so advanced in several years; for instance, the bio-applications of polymer gel composites that involve micro/nanoparticles to be embedded in polymer gel have been many observed. This complex material composition can express a specific property and low toxicity so it can be used in various domain uses. Besides, the polymers material must possess certain properties to be utilized in the biomedical application (magnetic hyperthermia, cancer therapy, and food industry) such as flexible, biocompatibility, and water swallowability. Magnetite is nanoparticle with a unique property that can be utilized as a filler. The low toxicity of magnetite under the superparamagnetic condition is very useful in biomedical application. This research was succeeded to synthesize PVA/PVP polymer-based hydrogel magnetic with PEG-coated magnetite with Manganese doping filler, which has good biocompatibility and stable particle. An advanced characterization using XRD has shown the crystallite size about 9-11 nm with the magnetite phase confirmed from the sample. The SAXS analysis using two-lognormal functions exhibited primary and secondary particles around 2.40 and 9.74 nm that was well proven by TEM image analysis that showed a close value of the average particles size about 9.78 nm. From the SAXS and TEM analysis, it could be observed that the samples formed clusters from primary and secondary particles.