Study on deliberate hypotension of dexmedetomidine hydrochloride in patients undergoing spinal surgery

Abstract

Objective To investigate the safety and feasibility of deliberate hypotension with dexmedetomidine hydrochloride ,as well as the effects on cerebral oxygen metabolism and postoperative cognitive function. Methods Sixty patients who underwent posterior lumbar interbody fusion were randomly divided into group D and group N,30 in each group. Both groups were anesthetized with same methods. In group D, intravenous administration of dexmedetomidine hydrochloride 0.5μg/kg followed by reduce the MAP to 30%, which was maintained for 70 minutes. Record MAP, HR,ECG,BIS,SEVO%,and arterial blood samples and jugular blood samples were taken synchronously for measuring blood gas,MMSE were recorded before and after operation .Reaulta Compared with N group,heart rate of D group decreased significantly from time T2 to T5 (P＜0.05), the mean arterial pressure in group D was increased at T5 and increased at T6(P＜0.05). The level of CERO2 and MMSE showed no significant change(P＞0.05).C onclusions The patients of deliberate hypotension with dexmedetomidine hydrochloride was safe and feasible. It had no effect on the cerebral oxygen metabolism and postoperative cognitive function. Key words: Dexmedetomidine hydrochloride; Deliberate hypotension; Cerebral oxygen metabolism