Abstract
Background: In chronic kidney disease (CKD) patients,measuring carotid artery intima– media thickness (CIMT) canpredict coronary heart disease and stroke, resulting from systemic atherosclerosis.Objective: To find out correlation of carotid artery intima–media thickness and dyslipidemia in chronic kidney disease in a Bangladesh population.Methods: A cross-sectional analytic study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladeshi, between July 2014 and June 2015, on 80 CKD patients. Standard laboratory techniques were followed to estimate all biochemical parameters. CIMT measurement was done by duplex study of carotid vessels through high resolution B-mode ultrasound technique.Results: Among 80 patients, 29 (36%) were in 18-30 age group, 18 were (23%) 31-40 age group and 33 (41%) were between 41-50 age group; mean age was 36.1±9.5 years. 51 (64%) patients were male and 29 (36%) were female. Though mean CIMT was found markedly increased in all CKD patients, the differences among stage 3, 4 and 5 was not significant. Mean CIMT was found more in dyslipidemic patients in comparison those with normal lipid profile, which was statistically significant (p<0.05). Positive correlations were found between total cholesterol (TC) and CIMT (r=+0.295; p=0.008), triglyceride (TG) and CIMT (r=+0.238; p=0.034), and lowdensity lipoprotein (LDL) and CIMT (r=+0.231; p=0.039). However, there was negative correlation between high-density lipoprotein (HDL) and CIMT (r=–0.242; p=0.030).Conclusion: Our data suggest that the mean carotid intima-media thickness was markedly high in patients with CKD in comparison to normal expected value; however, there was no significant difference in thickness among CKD stages 3, 4 and 5. It was also observed that carotid artery intima-media thickness showed significant positive correlation with total cholesterol, triglyceride and LDL, but negative correlation with HDL.International Journal of Human and Health Sciences Vol. 04 No. 04 October’20 Page : 271-276
Highlights
Chronic kidney disease (CKD) and cardiovascular disease (CVD) are two important emerging non-communicable diseases and global health concerns in the 21st century[1]
Dyslipidemia is highly prevalent among CKD patients; it appearsin the early stages of renal insufficiency and as CKD progresses, it becomes more intense, and consequential to fatal outcome10,11.to our knowledge, the correlation of traditional cardiovascular risk factors and stages of chronic kidney disease (CKD) with carotid artery intima– media thickness (CIMT) has not been studied yet in our country.Several population-based studies in the Western countries showed that ethnicity or factors linked to ethnicity might have direct or indirectinfluence on atherosclerotic behaviour of blood vessels to initiate or worsen cardiovascular disease in individuals[9]
Our population demands scientificevaluation and studieson the relation between CIMT and cardiovascular risk factors or event in CKD patients.With this view in mind, the aim of our study was to find out correlation of carotid artery intima–media thickness and dyslipidemiain chronic kidney disease in a Bangladeshi population
Summary
Chronic kidney disease (CKD) and cardiovascular disease (CVD) are two important emerging non-communicable diseases and global health concerns in the 21st century[1]. Carotid artery intima–media thickness (CIMT) is a well-established canpredict coronary heart disease and stroke resulting from of systemic atherosclerosis in chronic kidney disease (CKD) patients[8,9].
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