Abstract
Introduction: Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic specific antigen levels in the blood go up if the barrier between the lining epithelium and the blood stream is damaged. This study was done to determine the correlation between serum Prostatic specific antigen level and histological diagnosis in prostatic biopsy.Material and Methods: This is a one year prospective study carried out in the Department of Pathology, Nobel Medical College from August 16, 2016 to August 15 2017. A total of 175 cases were included in the study. Patient Prostatic specific antigen level were noted and biopsy specimen was collected after operation. Histopathological examination was done and correlation between HPE diagnosis and serum Prostatic specific antigen level was done.Results: Benign Prostatic Hyperplasia was the most common diagnosis that was encountered. Majority of the cases had a serum Prostatic specific antigen level less than 10 ng/ml. Serum Prostatic specific antigen level of more than 30 ng/ml was seen only in prostatic carcinoma.Conclusions: Serum Prostatic specific antigen is organ specific but not a disease for prostate. It can be used to monitor the carcinoma of the prostate rather than the diagnosis of the carcinoma.
Highlights
Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction
Adenocarcinoma of Prostate contributed in a total of 15 cases (8.57%)
A total of 14 patients were included in the study with the age group of > 80 years. 7 (50%) of the patients were those of Carcinoma Prostate
Summary
Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction. Prostatic specific antigen is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted. Prostatic specific antigen is a widely used tumor marker for prostatic cancer. Prostatic enlargement that may due to any cause may give rise to bladder outlet obstruction.[1] It is a male specific organ and the rate of clinical symptoms due to obstruction of the bladder neck goes up as the age rises due to increase in prostatic volume.[2] Prostate specific antigen (PSA), a glycoprotein serine protease, which was first identified by Wang et al in 1979.3. PSA is the enzyme that is responsible for liquefaction of semen within a few minutes after it has clotted.[4] Prostate – specific Antigen (PSA) is a widely used tumor marker for prostatic cancer.
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