Study on Correlation Between Leptin, IGFIIand Endometrial Cancer

Abstract

Objective To explore the expression of Leptin and insulin-like growth factor Ⅱ (IGFⅡ)in peripheral blood in endometrial cancer patients and the significance of its expression differences in the development of endometrial cancer. Methods According to FIGO(2009), the study object were respectively divided into five groups: control group(n=40), stageⅠgroup(n=15), stage Ⅱgroup(n=10), stage Ⅲgroup(n=8)and stage Ⅳ group(n=7). The expression of Leptin and IGFⅡ in peripheral blood of the study object were measured by enzyme-linked immunosorbent assay(ELISA). The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of The Affiliated Huai'an Hospital of Xuzhou Medical College. Informed consent was obtained from each participating patient. Results The level of Leptin and IGFⅡ in endometrial cancer patients were increased significantly in stageⅠgroup, stageⅡgroup, stage Ⅲgroup and stage Ⅳgroup compared with control group. The data has significant difference(P<0.05). Conclusions The study shows the expression of Leptin and IGFⅡ increased with the rising of endometrial cancer staging. The expression of Leptin and IGFⅡ significantly increase may be one of mechanisms to promote the development of endometrial cancer. Leptin and IGFⅡand their participation in a variety of reaction have certain relevance with the development of endometrial cancer. Key words: endometrial neoplasma; Leptin; insulin-like growth factorⅡ