Abstract
Objective To evaluate the correlation between he art rate variability and brain natriuretic peptide (BNP) in patients with type 2 diabetes and left ventricular diastolic dysfunction.Methods 100 patients with type 2 diabetes were included,all the patients' BNP level were over 100 pg/ml.SDNN-Index,RMSSD,PNN50 and BNP were measured,data were presented as (M ± SD).The correlation between heart rate variability and BNP level was assessed by Pearson Correlation Analysis (SPSS software).Results The correlation coefficient between SDNN-Index [(46.41 ± 17.74) ms] and BNP level was-0.472 (P ＜ 0.01);The correlation coefficient between RMSSD [(37.18 ± 19.07) ms] and BNP level was-0.434 (P ＜ 0.01); the correlation coefficient between PNN50[(18.88 ± 15.21)％] and BNP level was-0.589 (P ＜ 0.01).Conclusion The heart rate variability in patients with type 2 diabetes and left ventricular diastolic dysfunction is obviously lower than that of normal people,and significantly correlated with BNP level. Key words: Type 2 diabetes; Left ventricular diastolic dysfunction; Heart rate variability; Brain natriuretic peptide
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