Abstract
Objective To explore the cognitive function and event related potential N400 of old patient with depression in remission.Methods Twenty-three elderly person aged 60 and over (depression group) with depression who met diagnostic criteria according to CCMD-3 and 20 elderly healthy person (control group) were investigated.All subjects were interviewed with HAMD，MMSE，MoCA and event-related potential N400 were measured.The correlation between cognition and event-related potential N400 and its diagnostic value for depression in the elderly was analyzed.Results The score of MMSE and MoCA were significantly lower in depression group than in control group (P<0.05).N400 latency in depression group were significantly longer than those in control group (P<0.05).N400 amplitude in depression group were significantly lower than those in control group (P<0.05).The latency and amplitude of N400 significantly correlated to the score of MMSE and MoCA.Discriminant analysis found that the score of MMSE，the amplitude of Pz and the latency of C3 showed valuable in the diagnosis of senile depression.Conclusions The findings suggest that remitted senile depression patients have impairment in their cognitive function and N400.Event related potential N400 is valuable in the diagnosis of depression in the elderly.
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