Abstract
It is now widely recognized that coenzyme B_(12)-dependent rearrangements are caused by homolytic dissociation of the Co-C bond giving rise to a 5'-deoxyadenosyl radical. The Co-C bonding strength is related to the electronic and steric effect of the 5'-deoxyadenosyl radical and the axial organic base, playing a key role in the catalytic cycle. To clarify the mechanism of Co-C bond breaking in coenzyme B_(12), many experimental and theoretic researches on B_(12) model compounds have been conducted, especially on the effect
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