Abstract
Objective: To investigate the value of CTC clinical features and blood-related test indicators in renal cancer patients by detecting the number of circulating tumor cells (CTC) in patients with renal cancer. Methods: To analyze 59 patients with renal cell carcinoma (RCC) admitted to the Department of Urology, Affiliated Hospital of Chengde Medical College from May 2018 to October 2019. According to the CTC count (5 pcs/3.5 ml), they were divided into CTC positive group and CTC negative group. The age, gender, tumor location, tumor size, hematuria, CEC (circulating endothelial cells), CTC Cluster (aggregate), gene mutation, platelet (PLT), albumin (ALB), hemoglobin (HB), alkaline phosphatase (AKP), lactate dehydrogenase (LDH) were compared between the two groups of patients and the correlation of the number of CTCs. Results: There were significant differences in tumor size, CEC, and gene mutations between the two groups (P Conclusion: The number of CTC in RCC patients is correlated with some clinical features (tumor size, CEC, gene mutation) and some related test indicators (HB, PLT, LDH), and can be combined with the above related indicators to predict the occurrence, metastasis and prognosis of renal cancer.
Highlights
The number of circulating tumor cells (CTC) in renal cell carcinoma (RCC) patients is correlated with some clinical features and some related test indicators (HB, PLT, lactate dehydrogenase (LDH)), and can be combined with the above related indicators to predict the occurrence, metastasis and prognosis of renal cancer
This study explored the application value of CTC detection in renal cancer by detecting the number of CTCs in patients with renal cell carcinoma, the relationship with various clinical characteristics and various clinical blood test indicators
3) The number of CTC is correlated with the levels of HB, PLT and LDH in patients with renal cell carcinoma (P < 0.05) (Table 3)
Summary
The current important problem facing RCC is how to prevent tumor recurrence and metastasis. The first is the shedding of tumor cells from the primary tumor, and a very small number of them will metastasize to the blood, lymph nodes or distant organs, which is called tumor micrometastasis [5]. This kind of micro-transfer is difficult to detect with the current routine inspection methods. CTC is considered to be an important basis for hematological metastasis of malignant tumors, and has always received clinical attention [6]. This study explored the application value of CTC detection in renal cancer by detecting the number of CTCs in patients with renal cell carcinoma, the relationship with various clinical characteristics and various clinical blood test indicators
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