Study on Changes of the Concentration of Some Indicators of the Serum Iron Test in Patients with Nephrotic Syndromein Vietnam

Abstract

Background: In nephrotic syndrome (NS), the excessive and prolonged loss of protein in the urine reducesalbumin blood and leads to many other changes such as dyslipidemia, blood clotting disorders, and disordersof hematopoietic components. In NS, the more persistent and persistent decrease in albumin in the blood, themore apparent these disorders, including disorders of iron, transferrin and ferritin in serum. The objectivesof the study were to: Determine serum iron, transferrin and ferritin concentrations and Investigate therelationship between iron, transferrin and ferritin concentrations and serum albumin in NS patients.Methodology: Cross-sectional descriptive research method. Convenient and controlled sample selectionof 68 NS patients without kidney failure, aged 16 years and over, hospitalized for treatment at InternalDepartment of Hue University of Medicine and Pharmacy Hospital, Vietnam.Results: The average serum iron concentration is 8.9 µmol/L, of which at low level, the rate is 30.9%; In100% of cases, the serum transferrin concentration is lower than normal, the average concentration is 0.68mmol/L; the average elevation of ferritin in serum was 610.3 pmol/L, of which at high level accounted for67.6% (46 patients). Serum albumin concentrations are positively correlated with iron and transferrin, butnegatively with serum ferritin.Conclusion: In NS, the serum ferritin concentration is elevated and inversely correlated with the serum iron,transferrin, and albumin concentration.