Study on Cell Behavior on Surfaces with Various Nanostructured Modifications

Abstract

Several researchers have developed finite element analysis (FEA) models on dental implants; however, few have used it to investigate the effects of nanosurface treatment on the cell-implant interface. For cell proliferation and differentiation are believed related to the physical stimulations of modification surfaces. In the present study, the cell adhesion affected by mechanical stimulation from substrate was evaluated by culturing the MG-63 osteoblast-like cells on Ti materials with different chemical composition using computer-aided programs. Three types of surfaces were made by mechanically abraded, anodized and anodized following with hydrothermal treatment on Ti substrates. The cell adhesion behavior was promoted because the physical stimulation of specific surface topography provided cells mechanical external forces. The finite element analysis (FEA) was used to investigate the deformations stresses which cells were suffered on these 3 different modifications surfaces. Results indicated that cells in the HTT group were received larger stimulation of deformations and stresses than the control group (P > 0.01). This confirmed that the superior cell proliferation and differentiation resulted from the specific roughly surfaces of HYT surface for implants.