Abstract
Objective To study the biocompatibility of silk fibroin (SF) with placenta mesenchymal stem cells (PMSCs).Methods PMSCs were cultured in the SF coating flasksand and its phenotype was analyzed by flow cytometry,while its adipogenic,chondrogenic,and osteogenic differentiation potential were determined by staining.The growth condition was then observered under the electric microscope.Results After being cultured in the SF film,the growth characteristics,surface markers,multi-differentiation capacity of PMSCs did not change.The electric microscope observation results showed that PMSCs well proliferated in the SF film after been co-cultured for 8 days,and large amounts of granular was secreted,and mesh matrix substances well filled in the material clearance.Conclusion SF has good biocompatibility by showing no effects on the PMSCs growth characteristics,surface markers and multi-differentiation capacity. Key words: Silk fibroin; Placenta mesenchymal stem cells; Biocompatibility
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