Abstract
A carbon fiber microelectrode(CFME) modified with single-walled carbon nanotubes(SWNTs) was prepared,the surface morphology and electrochemical behavior of modified electrode was characterized by transmission electron microscope(TEM),cyclic voltammetry(CV),differential pulse voltammetry(DPV) and chronoamperometry.The experimental results showed that the SWNTs could significantly alleviate electrode fouling caused by 5-hydroxytryptamine(5-HT).In 0.2 mol/L Tris-HCl(pH 7.4) buffer,the amperomatric method was used for the determination of three consecutive injections of 1.0×104 mol/L 5-HT,the peak current decreased significantly successively at a CFME,and the third peak current was 43.4% of the first one.The peak current decrease slightly at a SWNTs-CFME and the third peak current was 97.3% of the first one,the peak current change was significantly less with the rising of test times,the results indicated that the SWNTs-CFME possessed stable electrochemical performance.The detection limit of 5-HT improved from 1.2×107 mol/L to 6.8×107 mol/L after SWNTs coating.The modified electrode-based microchip capillary electrophoresis system was successfully applied to detect 5-HT in rat blood plasma and the concentration of 5-HT was(6.96±0.24) ×107 mol/L(n=5),the recovery of standard addition was between 96.8% and 103.9%.
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