Abstract
The present study reveals the medicinal properties of the present study reveals the medicinal properties of the Cardiospermum halicacabum. The Cytotoxic activity of methanolic stem extract of Cardiospermum halicacabum was tested against breast cancer cell line (MCF-7) using MTT assay. The Cytotoxic activity of methanolic stem extract of Cardiospermum halicacabum showed significant activity against tested cell line. The different concentrations (100, 500, 1000) was tested at an optical density of 540nm was observed to calculate the percentage of viability. Hundred percent viability was seen against control. The maximum inhibitory activity was seen in lower concentration (100%) at a optical density of 6.753 was observed. The minimum percentage of viability (50%) was observed at an optical density of 0.392 was observed in 1000 µg/ml). From the results it can be observed that the added compounds produced significant decrease in cell viability which confirms antiproliferative activity of the studied extracts. Acridine orange fluorescent staining, Neutral Red staining and Lactose dehydrogenase assays were carried out in MCF-7 breast cancer cell lines to study apoptopsis. The plant extract has shown significant apoptoptic activity against cancer cell lines.
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