Study on a host–guest interaction of β-cyclodextrin with tebuconazole in water

Abstract

In order to assess the effect of β-cyclodextrin (β-CD) on the tebuconazole (TEB) solubility in water, UV–VIS spectroscopic measurements of the tebuconazole solutions with β-cyclodextrin were examined, followed by a VP-ITC calorimetric titration of the solutions of tebuconazole with β-cyclodextrin. The stoichiometry of the tebuconazole–β-cyclodextrin inclusion complex formed and the physical and chemical parameters describing the complex were determined. The effect of fungicide included inside the macromolecule of β-cyclodextrin on the fungal culture (hyphae) of Aspergillus fumigatus was also assessed.