Abstract
This study examines hormone secretions in a rabbit model to identify the effects of oral administration of ZnO nanoparticles on the thyroid gland and testes. For this purpose, thirty healthy rabbits were acclimatized and divided into control, experimental group 1 (EG1) and 2 (EG2). These groups were examined for 50mg/Kg and 75mg/Kg nanoparticle dosages. Experimental groups lose weight, while control doesn’t. Both groups had non-significantly lower Thyroid-stimulating hormone (TSH), triiodothyronine (T3) and Thyroxine (T4) levels. EG1 and EG2 had considerably lower testosterone levels on the 20th and 10th days of trials, respectively. In the experimental group, nanoparticles caused seminiferous tubule degeneration and germinal epithelium sloughing or depletion. Histology was normal in the control group. This present study provides a glimpse into the toxicity of nanoparticles; a more in-depth analysis using various animal models is needed.
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