Study of Xailin night physical Properties versus marketed ocular lubricant products

Abstract

PurposeXailin Night is a multi‐dose preservative free lubricating eye ointment for night‐time relief of dry eye sensations. It contains white soft paraffin 57.3% w/w, white mineral oil 42.5% w/w and lanolin alcohols 0.2% w/w. Comparative studies were performed with Xailin Night against other marketed products in the EU in order to assess its key physical properties.MethodsTested products cover the whole range of ocular lubricants from oily formula to aqueous compositions. The parameters studied were the following: Viscosity and rheological behaviour (25°C and 35°C), capacity to slow down evaporation at 40°C and 70°C, spreading capacity at room temperature and 35°C, long‐lasting assessment. The products marketed in the EU assessed in this study were: Viscotears liquid gel, Lipolac, Celluvisc 4 mg/0.4 mL, Siccafluid 2.5 mg/g, Bepanthen, Vismed multi, Hyabak 0.15%, Artelac Nighttime Gel.ResultsAt room temperature, Xailin Night viscosity shows an intermediate profile included between low viscosity gels (Siccafluid) and very highly viscous products (Bepanthen, Viscotears and Lipolac). As expected, temperature has an effect on the rheological behaviour of ointments but not on the other products. No evaporation is observed for Xailin Night whatever the temperature, while all the other tested products show a slight evaporation. Lipolac and Viscotears have a superior spreading capacity compared to pure aqueous‐based products but remain significantly lower than ointments. As an ointment, Xailin Night has a superior long‐lasting effect than aqueous products.ConclusionsXailin Night is an ocular ointment with a strong long lasting effect and shows no evaporation compared to aqueous based ocular lubricants.