Abstract
BackgroundAttention deficit hyperactivity disorder (ADHD) is an early-onset neurodevelopmental disorder that can extend into adulthood with multiple reported neuroimaging abnormalities. The focus of this research was to assess white matter impairments in ADHD children’s fathers with and without potential adult ADHD to see if these differences are connected with the persistence of ADHD into adulthood.ResultsThe occurrence rate of the potential adult ADHD diagnosis among fathers of children with ADHD was 60%. There were statistically significant differences between fathers with ADHD and the non-ADHD population, due to the fact that the mean FA of the left superior corona radiata and the right posterior corona radiata were lower in the ADHD group than in the non-ADHD group, while the FA of the ADHD group was significantly greater than that of the non-ADHD group in terms of the left and right anterior thalamic radiations, the right superior longitudinal fasciculus and the left anterior corona radiata.ConclusionsWe observed an increased prevalence of ADHD in fathers of children diagnosed with ADHD. Fathers with potential adult ADHD have a variety of white matter abnormalities that reflect the neurobiological basis of ADHD, even in sub-threshold cases. This may provide insight into the neuroanatomical locations associated with the maintenance of ADHD throughout adulthood.
Highlights
Attention deficit hyperactivity disorder (ADHD) is an early-onset neurodevelopmental disorder that can extend into adulthood with multiple reported neuroimaging abnormalities
Diffusion tensor imaging (DTI) is an approach that is equivalent to magnetic resonance imaging (MRI) that can be utilized to detect white matter (WM) pathways by providing information about the diffusion of water molecules
A suitable sample of children associated with ADHD was drawn from the child outpatient clinics of the Institute of Psychiatry Ain Shams University in Cairo, Egypt, which are localized in the eastern part of the city and serve roughly a third of bigger Cairo’s population
Summary
Attention deficit hyperactivity disorder (ADHD) is an early-onset neurodevelopmental disorder that can extend into adulthood with multiple reported neuroimaging abnormalities. The focus of this research was to assess white matter impairments in ADHD children’s fathers with and without potential adult ADHD to see if these differences are connected with the persistence of ADHD into adulthood. Instead of focusing on regional impairments, neuroimaging studies in ADHD have turned toward a connectivity strategy that studies the functional and anatomical association between brain regions. With this perspective, the pathophysiology of ADHD is viewed from the perspective of organizational dysfunctions of the distributed. Diffusion tensor imaging (DTI) is an approach that is equivalent to magnetic resonance imaging (MRI) that can be utilized to detect white matter (WM) pathways by providing information about the diffusion of water molecules. FA is highest in compact and well-myelinated fibers, whereas low FA is related to WM degradation [6]
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