Abstract

Urticarial wheal is due to the leak of proteins and fluids to extravascula by increased capillary permeability. Edematous erythema and wheals located in the surface of gastric mucosa were observed by gastroscopy. The present contribution is the first in the international extent of the observation of wheals on gastric mucosa of 38 patients with chronic urticaria with the transmission electron microscope (TEM) and scanning electron microscope (SEM).Gastroscopies were performed on 38 patients with chronic urticaria during episodes ofcutaneous wheals. Biopsy specimens were taken from gastrical wheals from 38 patients. The EM specimens were routinely prepared. Linder the SEM, the surface of the epithelial cells of wheals on the gastric mucosa appeared slightly edematous and rough. Intercellular space of the epithelium became more narrow and shallow. The structure of microvillae on gastric mucosa epithelial cells could be seen, but appeared short and decreasing in amount. Under the TEM, it was found that the stomach mucous membrane was edematous.

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