Abstract
Study of vitamins, antioxidant and trace elements on various spirometric parameters and quality of life in patients of bronchial asthma - IJCAAP- Print ISSN No: - 2581-5555 Online ISSN No:- 2456-9542 Article DOI No:- 10.18231/j.ijcaap.2019.030, IP International Journal of Comprehensive and Advanced Pharmacology-IP Int
Highlights
Imbalance between reactive oxygen species and antioxidant defence mechanism produce oxidative stress which further augments and aggravates airway inflammation in asthma
Bronchial asthma is a chronic inflammatory disease of the airways, characterized by hyper-responsiveness and airflow limitation leading to recurrent attacks of breathlessness, wheezing and disease exacerbation which varies in severity and frequency.[1]
By reducing external attacks in the lung and neutralizing oxidants effects, antioxidants vitamins modulate the development of asthma and the impairment of pulmonary function.[6]
Summary
Imbalance between reactive oxygen species and antioxidant defence mechanism produce oxidative stress which further augments and aggravates airway inflammation in asthma. The objective of this study is to find out the effect of antioxidants, trace elements supplementation on pulmonary functions and quality of life in asthmatics. Spirometric parameters (FEV1%) and quality of life were assessed at baseline and at regular intervals and the results were compared between the groups. Conclusion: From the results of our study, it was concluded that there was no additional benefit of vitamins, antioxidant, trace elements supplementation on pulmonary functions and quality of life in asthmatic patients. Bronchial asthma is a chronic inflammatory disease of the airways, characterized by hyper-responsiveness and airflow limitation leading to recurrent attacks of breathlessness, wheezing and disease exacerbation which varies in severity and frequency.[1] Its burden on society is enormous and imposes negative impact on the clinical outcome and quality of life of patient. WHO estimate of asthmatic patients in India is 15- 20 million.[3] Globally prevalence of asthma increases by
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