Abstract
BackgroundVitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms—Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)—in a cohort of CAD patients after acute myocardial infarction.MethodsIn the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR.ResultsThe results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction.ConclusionThe presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.
Highlights
Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD)
A study of both vitamin D binding protein (VDBP) and vitamin D receptor (VDR) polymorphisms in CAD patients showed a strong association between the VDR and VDBP genes polymorphisms and vitamin D deficiency [13], and the latter was evaluated as a possible risk factor in CAD pathogenesis [14]
The value of blood pressure was under the cutoff for arterial hypertension (AH) in both groups; the difference was not considered relevant for this study
Summary
Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). A recent meta-analysis reports on a lack of Fok, Taq and BsmI polymorphisms’ association with CAD [10]. A study of both VDBP and VDR polymorphisms in CAD patients showed a strong association between the VDR (rs1544410, G > A) and VDBP (rs7041 T > G) genes polymorphisms and vitamin D deficiency [13], and the latter was evaluated as a possible risk factor in CAD pathogenesis [14]. We expanded our research conducted on VDBP polymorphisms in a CAD cohort with myocardial infarction to the analysis of the Fok (rs2228570), BsmI (rs1544410) and Taq (rs731236) VDR polymorphisms as well. Our study provides evidence for association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction
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