Abstract
Oral mucoadhesive dosage formulations reveal numerous advantages they offer, like easy application, discrete handling and no need to swallow the drug product. Nevertheless, in order to ensure correct performance of these preparations, they must show suitable physicochemical properties, such as sorption and wetting, viscosity and adhesion to mucous membrane. In this study, the physicochemical properties of selected mucoadhesive polymers and their blends composed of acrylic acid polymers (Carbopol 974P NF, Noveon AA-1), cellulose derivatives (HEC, HPMC) and film-forming polymer (Kollidon VA 64) were examined. The tested formulations have been analyzed by techniques, such as flow rheometry, oscillatory rheometry and liquid penetration method. Moreover, the mucoadhesive strength of the investigated formulations was measured with the use of a texture analyzer. The tests have shown that the blends of anionic and nonionic polymers show significantly worse adhesive properties than the discs containing only Carbopol 974P NF or Noveon AA-1.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
