Study of vinpocetine adsorption on the surface of liposomes obtained from soya lecitine

Abstract

Liposomes are one of the best studied types of nanoparticles that are considered as contemporary and efficient means for delivery of various medicinal agents widely applied in the clinical practice. Taking into account the features of transportation, translocation through histological barriers, cellular membranes and metabolic transformations liposomal pharmaceutical drugs show unique properties, first of all connected with the distinctions in their pharmacokinetics. Objective of the study: determination of adsorption characteristics for vinpocetine applied on the surface of liposomes obtained from soya lecitine. Liposomes from soya lecitine were obtained by hydration/rehydration technique. In order to study characteristics of vinpocetine adsorption on the surface of liposomes technique of equilibrium dialysis was utilized. Sol of iron hydroxide was used as a comparison adsorbent. Separation of the dispersive medium from sol colloid particles was performed with the use of column chromatography. Comparative investigations of vinpocetine adsorption were performed both on comparison adsorbent and on the liposomes obtained from soya lecitine. Rather efficient adsorption of vinpocetine on the liposomes at their low concentrations was observed.