STUDY OF VIMENTIN EXPRESSION IN TRIPLE NEGATIVE BREAST CANCER

Abstract

Background: Breast carcinoma is one of the most common cancer among women globally. Increased vimentin expression has been reported in triple negative breast carcinoma (TNBC) cases. This study showed the expressi Aims And Objective: on of vimentin in TNBC cases and its correlation with various prognostic factors such as age, tumor size, histological grade and lymph node status. This study Materials And Method: was conducted at Department of Pathology, Gandhi Medical College, Bhopal from January 2021 to June 2022. Total 60 breast cancer specimens (mastectomy, lumpectomy, biopsy) were submitted for histopathological diagnosis and Estrogen receptor (ER), Progesteron receptor (PR) and HER2/neu expression. Out of 60 cases, 21 cases were showing triple negativity and selected for vimentin expression study. Results: In the present study out of 21 TNBC cases, 19 cases (90.5%) had shown positive vimentin expression. The mean age of cases was 52.6years and tumor size >2cm. Signicant correlation was seen between vimentin expression and tumor size, as the tumor size increases vimentin expression also increases. Majority of cases (76.2%) were positive for nodal metastasis. In TNBC cases with positive vimentin expression, 47.6% cases belonged to grade III, 42.9% cases grade II, and 9.5% cases of grade I. As the grade of tumor increases, vimentin expression also increases. Conclusion: The vimentin expression in the present TNBC cases demonstrated signicant vimentin expression which can be helpful in detection of metastasis and disease prognosis