Abstract
In this paper, human umbilical vein endothelial cells (HUVECs) cultured in vitro were used to observe the hyperthermia effect on the dynamic change of the endothelial cell shape and cytoskeletons. A tumor environment was simulated using the ECM625 gel. Hollow tube-like structures were formed of endothelial cells and their focal adhesions were found fewer than those cultured on gelatin. Intercellular gap size increased significantly during hyperthermia. Results showed that cells in the G0/G1 phase or with fewer nucleoli were thermally less sensitive. This suggests that the efficacy of tumor anti-angiogenesis therapy may be promoted by arresting the endothelial cells in the S/G2 phase and applying hyperthermia simultaneously.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
