Abstract
Aim: The present study was undertaken with the aim to investigate influence of hormonal fluctuation duringmenstrual cycle on ECG.Materials and Method: The present study was carried out on 30 healthy female medical students in theage group of 18 to 23 years with normal menstrual cycle of 27-33 days. ECG was recorded on 2nd,11th,22ndday of menstrual cycle (corresponding with menstrual phase, proliferative phase and secretory phase ofmenstrual cycle), using AD INSTRUMENT–POWERLAB®/30 Series.Results: The study revealed that Heart rate was significantly (P<0.05) increased in secretory phase(98.26±10.44) compared to menstrual phase (91.85±10.27).QT and QTc interval showed increase duringproliferative phase but not significant.Discussion: Fluctuation in both estrogen and progesterone during menstrual cycle influence not only phase-II of cardiac action potential but also autonomic tone which could have led to prolonged QTc in Proliferativephase and increase in heart rate during secretory phase in present study, which provides a screening toolto avoid morbidity due to intake of drugs which prolonged QTc interval during menstrual cycle. But QTcinterval in present study was not increased significantly as it was done during single cycle.
Highlights
Women are at higher risk than men, of developing a dangerous drug-induced cardiac arrhythmia that can be fatal
The cyclical fluctuations in the levels of FSH, LH, oestrogen and progesterone changes occurring during menstrual cycle affect oocyte maturation and the endometrial and vaginal environment but can effect on the cardiovascular system which are of immense clinical significance[4]
Aims and Objectives: The present study was undertaken with the aim to investigate influence of hormonal fluctuation during menstrual cycle on ECG, with an objective to compare heart rate, QT interval and QTc interval in ECG changes during different phases of menstrual cycle
Summary
Women are at higher risk than men, of developing a dangerous drug-induced cardiac arrhythmia that can be fatal. This risk may be heightened during menstruation and ovulation[1]. The menstrual cycle is a repetitive phenomenon occurring during the reproductive life of a female that involves a patterned sequence of structural, functional and hormonal changes in the reproductive system[3]. It is a window into the general health and well-being of women and not just are productive event. The cyclical fluctuations in the levels of FSH, LH, oestrogen and progesterone changes occurring during menstrual cycle affect oocyte maturation and the endometrial and vaginal environment but can effect on the cardiovascular system which are of immense clinical significance[4]
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