Abstract
The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.
Highlights
Over the last two decades, incidence of asthma has increased, and asthmatics are at risk for acute exacerbations requiring emergency care[1]
A linear correlation was present between urinary leukotriene E4 levels and serum 1Professor of Paediatrics, 2Resident of Pediatrics, 3Senior Resident of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research Mysore, India *Corresponding author: prashanthsnped@yahoo.co.in https//orcid.org/ 0000-0002-2520-7310 (Received on 08 February 2021: Accepted after revision on 19 March 2021) The authors declare that there are no conflicts of interest Personal funding was used for the project
There was a significant difference in total serum IgE levels between mild, moderate, and severe exacerbation groups and it was more in the severe group. (p
Summary
Over the last two decades, incidence of asthma has increased, and asthmatics are at risk for acute exacerbations requiring emergency care[1]. Cysteinyl leukotrienes (cys-LTs) C4, D4, and E4 play an important role in asthma pathogenesis[2,3]. They increase bronchial hyperreactivity and constrict bronchial smooth muscle[4]. Which is further converted to a less potent LTE4, the most stable of the three metabolites and this is excreted in the urine[5,6]. To assess changes in the rate of total body cys-LT production, estimation of urinary levels of LTE4 can be done[5]. Leukotriene (LT) E4, which is the most stable cysteinyl LT, is excreted in the urine and its concentration is raised in acute exacerbation of asthma. Estimation of urinary levels of LTE4 can assess changes in total body cysteinyl LT production
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