Study of trimester wise effect of hypothyroidism in pregnancy and its materno- fetal outcome

Abstract

Introduction: Pregnancy is associated with a number of physiological and hormonal changes that result in significantbut reversible alterations in thyroid function tests (TFTs). Production of thyroid hormones and iodine requirement eachincreases by approximately 50% during pregnancy.Methodology: All the patients coming to OPD for regular antenatal visits, after obtaining the gestational age and informedconsent were randomly selected for the study. The patients fulfilled all the inclusion criteria. A detailed history wastaken regarding, The symptoms, and signs of thyroid disorders, menstrual history, obstetric history, past medical history,family history and personal history.Results : In our study , while we analysed , trimester wise effect of hypothyroidism in pregnancy and it’s meterno-fetaloutcome , we found , mothers who were detected with thyroid disorder in first trimester were more with pregnancyassociated complications (45% ) as compared to second trimester (21%) and third trimester ( only 3%)Conclusion: From this study , we conclude that maternal hypothyroidism is associated with a variety of neonatal andpregnancy related adverse events like abortion,fetal growth restrictions, Oligohydramnios, gestational hypertensionpreterm delivery,operative delivery.