Abstract
Cadmium has been known to be harmful to human healthy , manily Via contaminated drinking water , food supplies , tobacco and industrial pollutant . The aim of this study was to determine the toxicity of new Cadmium (II) complex ( Bis[ 5- ( P- nitrophenyl ) – ? 4 – Phenyl- 1,2,4- triazole -3- dithiocarbamatohydrazide] cadmium (II) Hydra ( 0.5) and compare it with anticancer drug cyclophosphamide ( CP) in female albino mice . This complex causes to several alterations in Enzymatic activity of Glutamate Pyruvate Transaminase (GPT) and Alkaline Phosphatase (ALP ) in three organs after the treatment of mice with different doses of a new cadmium (II) complex ( 0.09 / 0.25ml , 0.18/ 0.5ml and 0.25mg /0.7 ml /30 gm of mouse ) for three days by the decreased of Glutamate Pyruvate Transaminase activity in lung , Liver and kidney , while the Alkaline Phosphatase activity was increased in kidney , lung and liver . The results were indicated that no significant differences ( P > 0.05 ) in Glutamate Pyruvate Transaminase activity between the treatment of mice with cadmium ( II ) complex and cyclophosphamide (CP) in the liver , kidney and Alkaline Phosphatase activity in the liver at each three doses .
Highlights
Chemotherapy is the use of synthetic chemicals or drugs extracted from plants these compounds are toxic against cancer cells, inhibiting their reproduction and division [1]
Pierpaoloetal [7] were investigated the characterize of cadmium – induced apoptotic response in normal and tumor cells derived from human prostate epithelium at dose relevant to human exposure, CdCl2 to induce cytotoxic in the human lung carcinoma cell line in the lower micromolar concentrations
The results present an evidence that treatment with cadmium (II) complex showed the inhibition in enzymatic activity at three doses was reached to 94.23 % in the lung, 93.95% in the liver and 90.96% in the kidney comparably with control at 0.09 mg / mouse
Summary
Chemotherapy is the use of synthetic chemicals or drugs extracted from plants these compounds are toxic against cancer cells , inhibiting their reproduction and division [1]. Some heavy – metal cations e.g. Hg+2, Cd+2 and Ag+ from strong toxic complexes which make them too dangerous for any physiology function [3]. Filipic , et al [4] presented evidence that when assayed in a test system , in which both intragenic and mutations could be detected , cadmium acts as a strong mutagen which induces predominantly multilocus detections. Transition metal complexes with dithiocarbamates as a ligands have been extensively investigated and were of interest in many fields ;as flotation agents and as antifungal agents [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
