Abstract
Some metal complexes of isoniazide hydrazones of 1, 3-diketone, such as acetylacetone (AA)-INAH-Ni, AA-INAH-Cu, AA-INAH-Cd, thenoyltrifluoroacetone (TTA)-INAH-Cu, TTA-INAH-Ni, TTA-INAH-Zn, trifluoroacetylacetone (TAA)-INAH-Ni, furoyltrifluoro-acetone (FTA)-INAH-Cu and benzoylacetone (BA)-INAH-Cu (Group I) were prepared. These complexes are very stable and hardly soluble in water or alcohol. Some complexes of different type, such as BA-benzoylhydrazide (BH)-Ni-NH3 and TTA-BH-Cu-NH3 (group II) were also prepared. Elementary analyses indicated that the ratio of metal to ligand is 1 : 1 in group I and that of metal to ligand and ammonia is 1 : 1 : 1 in group II. Nuclear magnetic resonance : In the complexes of group I, the coordination to N of pyridine in isoniazide moiety was suggested. On the other hand, in the complexes of group II the coordination of ammonia was observed. Infrared : Shifts of amide (I, II, III, III', and V) band and pyridine vibrations of chelates from their ligands indicated the existence of chelates of isoniazide hydrazones of 1, 3-diketones, coordinated to N of pyridine in the ligand molecule. Therefore, it is strongly suggested that complexes of isoniazide hydrazones of 1, 3-diketones have a structure of I in Chart 2 and ammine complexes of benzoylhydrazide hydrazones of 1, 3-diketone a structure of Chart 1.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
