Study of the Role of Adiponectin Gene Polymorphism in Patients with Thyroid Disorders

Abstract

Background: Both hypo & hyperthyroidism are associated with some morbidity & mortality. Adiponectin is a fat cell-derived hormone that protect against atherosclerotic cardiovascular diseases through its enhancing effect on insulin sensitivity. Clinical studies investigating serum adiponectin levels in patients with hypothyroidism and hyperthyroidism have reported conflicting results. Objective: The study aimed to study the role of adiponectin gene polymorphism in patients with thyroid disorders either hypothyroidism or hyperthyroidism. Also, the relation of adiponectin gene polymorphism with obesity and DM. Patients and Methods: Cross sectional study was conducted on one hundred and fifty cases that were classified into hypothyroid group and hyperthyroid group. History, examination and investigation (adiponectin gene) was done. Results: In current study within hypothyroid & hyperthyroid group, there was non-significant relation between gene polymorphism and either total T3, free T3, free T4 or TSH. There was statistically non-significant relation between associated diabetes and either gene or allele polymorphism among patients within hypothyroid group and hyperthyroid group. There was statistically non-significant relation between patient BMI and either gene or allele polymorphism among patients within hypothyroid group and hyperthyroid group. Conclusion: There was no role of adiponectin gene polymorphism and either total T3, free T3, free T4 or TSH. In addition, there was no role of adiponectin gene polymorphism and either obesity and DM.