Abstract
SUMMARY 1 We investigated the relationship between genetic and environmental factors in hypertensive people living in the Xinjiang Uygur Autonomous Region of China. 2 Body mass index, alcohol intake, serum total cholesterol, low-density lipoprotein-cholesterol and triglyceride level in the hypertensive group were significantly higher than corresponding values in the normal group. 3 Angiotensinogen gene polymorphisms and related haplotype H6 and H9 were strongly associated with essential hypertension. The b2-adrenergic receptor gene was associated with lipid disorders in Kazakhs in Xinjiang. 4 The results suggest that both genetic and environmental factors play an important role in the development of hypertension in Kazakhs in Xinjiang.
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