Abstract
Introduction: Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health (1). Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with end-stage renal disease (ESRD). Systemic inflammation is correlated with cardiovascular disease. Furthermore, parathyroid hormone (PTH) causes releasing of IL-6 from liver and osteoblast. IL-6 increases lifetime and activity of neutrophils. Therefore, PTH may have a direct correlation with neutrophil-to-lymphocyte ratio (NLR). Objectives: In this study, we aimed to determine the performance of NLR in hemodialysis and its possible correlation with PTH. Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and also Ca×P products (mg2 /dL2 ) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and also patients with or without chronic hypertensive disease. Results: This study consisted of 136 hemodialysis patients. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P>0.05). In addition, we test their correlation in other subgroups including hypertensive and normotensive, diabetic and non-diabetics, and male versus female patients. We found no significant correlation between iPTH and NLR in the mentioned subgroups, too. Conclusion: Observed correlation between PTH and NLR in hemodialysis patients may be due to our small sample size. Therefore, further studies on this subject are suggested.
Highlights
Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health [1]
In a study on 136 hemodialysis patients, we found no statistically significant correlation between intact parathormone and neutrophil-to-lymphocyte ratio in hemodialysis patients
Plasma intact PTH (iPTH) levels were found as 508.6 ± 528.08 pg/mL (Max; 2500, Min; 9.80 pg/mL), while neutrophil-to-lymphocyte ratio (NLR) was 2.52 ± 1.81 (Table 1)
Summary
Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health [1]. Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with endstage renal disease (ESRD). Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and Ca×P products (mg2/dL2) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and patients with or without chronic hypertensive disease. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P > 0.05). In a study on 136 hemodialysis patients, we found no statistically significant correlation between intact parathormone and neutrophil-to-lymphocyte ratio in hemodialysis patients. Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) elevate in patients with end stage
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