Study of the Relationship between Insulin-Like Growth Factor 1, Myostatin and Muscle Status in a Sample of Egyptian Patients on Hemodialysis

Abstract

Abstract Background Myostatin and IGF-1 are two biomarkers of muscle strength and muscle mass in patients on hemodialysis. These biomarkers are also able to detect low HGS values and are also associated with muscular mass. These biomarkers could be of clinical use as screening tools of sarcopenia in patients on hemodialysis. Aim of the Work The aim of this study is to evaluate the relationship between Insulin-Like Growth Factor 1 and myostatin and Muscle status (strength and mass) in a sample of Egyptian patients on Hemodialysis. Patients and Methods This study was a case control study conducted on 30 apparently healthy individuals as a control group and 30 patients on hemodialysis with muscle wasting attending hemodialysis unit at Ain Shams University Hospital to study the relationship between insulin like growth factor-1, Myostatin and muscle status in a sample of Egyptian patients on hemodialysis. Results This study results Showed Myostatin and IGF-1 are two biomarkers of interest to assess muscle status of dialysis patients. Both biomarkers are associated with HGS, Muscular mass. Regarding the comparison between the clinical examination and between our two groups we found that there were statically highly significantly difference between both groups regarding weight and BMI with P value (< 0.001) and shows that statically non significantly difference between both group regarding Age, height, dialysis vintage, DBP, Pulse with P-value (0.395). Conclusion In conclusion, our findings indicate that myostatin might be a useful biomarker for predicting muscle mass contents in hemodialysis patients, and serum IGF-1 might be a useful predictor of nutritional status including muscle mass in hemodialysis patients. Further studies of larger populations and longitudinal research are needed to confirm these results.