Study of the relation of Anti-Ro and Anti-La Antibodies with cardiac arrhythmia and other ECG abnormalities in Systemic Lupus Erythematosus

Abstract

Introduction: Arrhythmias and conductive system disorders are among the cardiovascular aggravations brought about by Systemic lupus erythematosus. Anti-Ro/SSA and LA antibodies are often recognized in connective tissue disease patients as well as in apparently healthy people. Aim of the work: Assess the role of Anti-Ro and Anti-La antibodies as hazard factors for arrhythmia in grown-up SLE patients.Patients and Methods: Cross_ sectional clinical investigation. A sum of 70 SLE cases going to the outpatient and inpatient divisions of rheumatology, Sohag University Hospitals; remembered for investigations. All members will be exposed to the accompanying: Full history, General and local assessment, Routine examinations: complete blood picture, erythrocyte sedimentation rate, liver capacities, kidney capacities, ANA IF, Anti Ro and Anti La appraisal by Immunoblot measure and ElectrocardiogramResults: 13 (41.9%) of our patients who had positive anti_ RO and LA had strange ECG findings, while 18 (58.1%) of them had typical ECG, just oral/nasal ulcers and Anti _RO/LA were an independent risk factor for abnormal ECG. Disease duration was nonsignificant and positive corresponded with disease activity by SLEDAI score Conclusion: This study exhibited that the grown-up heart may represent a goal for the anti_ Ro⁄SSA antibodies 'arrhythmogenicity. Notwithstanding, the particular rhythm changes happened appear to be, correlated with age, as shown by the way that while ventricular repolarization variations from the norm (specifically QTc prolongation) are the transcendent finding in the adults, the inclusion of conduction system is limited to the fetal heart only.