Abstract
BackgroundSeveral studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa. The aim of this study was to evaluate the protective action of the soluble fiber Plantago ovata husk against intestinal damage.MethodsTo evaluate the anti-ulcerogenic effect on duodenal mucosa of the soluble fiber Plantago ovata husk, low-dose acetylsalicylic acid (10 mg/kg) was given orally to animals once daily for 14 or 28 days with and without Plantago ovata husk (100 mg/kg). 24 h after final dosing duodenal samples were removed for anatomopathological evaluation. Villi were examined by both light and scanning electron microscopy.ResultsAcetylsalicylic acid induced severe lesions in duodenal mucosa of rabbits, including erosions, epithelium disorganization, and cell vacuolization, increasing as well the amount of mononuclear and caliciform cells. Damage was much more severe in animals treated for 28 days. In groups receiving Plantago ovata husk, a significant attenuation of acetylsalicylic acid-induced lesions was already observed in group treated for 14 days, becoming more evident in those treated for 28 days, all of them with duodenal cytoarchitecture normal and similar to control animals.ConclusionsThese findings suggest that Plantago ovata husk may protect intestinal mucosa probably by limiting acetylsalicylic acid penetration into epithelial cells, although further studies are needed to confirm the same effect in other experimental models of induced mucosal damage and to elucidate the mechanisms of fiber protection.
Highlights
Several studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa
Dietary fiber can be defined as an edible component of all plants which is resistant to digestion and absorption in the human gut but available for total or partial fermentation in the large intestine [1,2,3]
In rabbits treated with acetylsalicylic acid for 14 days small discontinuities were observed in glycocalix, and epithelium was disorganized and slightly vacuolized
Summary
Several studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa. Health benefits of high dietary fiber intake have been documented for centuries, it is not until recent decades that fiber supplements have gained increasing attention [4,5,6,7]. According to their physico-chemical properties, dietary fibers are classified as hydrosoluble, soluble or viscous (pectin, gum, mucilage, Plantago ovata husk) and waterinsoluble, insoluble or non-viscous We have used a well-known ulcerogenic agent (acetylsalicylic acid) that was orally administered for different periods of time (14 and 28 days) to rabbits
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