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Abstract
A survey of the prevalence of boric acid toxicity indicates the difficulty encountered in detecting cases of poisoning by this commonly used substance. Because of this situation, an investigation was carried out utilizing a previously reported method for the detection of borates by the polyvinyl alcohol-borate-iodine reaction. The test was extended in this study to permit the detection of boric acid in the urine of poisoned animals. Rabbits were fed varying quantities of boric acid, and urine samples were collected. After concentration of the urine sample, the polyvinyl alcohol-iodine reagent was applied to the residue. Results of both in vitro and in vivo studies indicate that this method is capable of detecting as little as 0.3 mg. of boric acid (0.05 mg. B). A survey of the prevalence of boric acid toxicity indicates the difficulty encountered in detecting cases of poisoning by this commonly used substance. Because of this situation, an investigation was carried out utilizing a previously reported method for the detection of borates by the polyvinyl alcohol-borate-iodine reaction. The test was extended in this study to permit the detection of boric acid in the urine of poisoned animals. Rabbits were fed varying quantities of boric acid, and urine samples were collected. After concentration of the urine sample, the polyvinyl alcohol-iodine reagent was applied to the residue. Results of both in vitro and in vivo studies indicate that this method is capable of detecting as little as 0.3 mg. of boric acid (0.05 mg. B).
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